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  App. Note 449: A Complete Toxicology Screening Procedure for Drugs and Toxic Compounds in Urine and Plasma Using LC-MS/MS
 The goal of this application note is to develop a complete LC-MS/MS screening methodology which includes a sample preparation method, LC-MS method, spectra library, and data processing and reporting software.
 


Conclusion:
The comprehensive, turn-key toxicology screening methodology described in this application note utilizes an LXQ ion trap, and includes an SPE procedure and LC method that enables the identification of 275 compounds in human urine and human plasma. Accompanying ToxID software performs automatic data analysis and reporting. This eliminates the need for manual data interpretation and increases confidence in compound identification. It is worth noting that when compared to other screening methods, the LC-MS/MS screening methodology identifies more analytes.

To read/download the complete note, use the link on this page.

   Products used for this Application
  Product #   Product Name   Image  
 IQLAAEGAAVFADCMAIL  LXQ Linear Ion Trap Mass Spectrometer      Select
 IQLAAEGACOFAIGMATQ  ToxID Software Automated Toxicology Screening Software      Select
 IQLAAEGAAUFAIGMAVW  ToxSpec Analyzer      Select